Wednesday, November 30, 2011

Green Tea Affects Genes to Improve Cholesterol Metabolism

Green tea consumption has beenshown to benefit many health issues ranging from help with weight management tocancer prevention and treatment. New research publishedin the British Journal of Nutritionexplains that the natural extract from the Camellia sinensis plant has a powerful effect on cholesterolmetabolism in the human body.

Most forward thinking health professionals now understand that dysfunctionin the LDL cholesterol pathway lays the foundation for cardiovascular healthproblems, cancer and fatty liver disease. Regular green tea consumption is nowshown to improve healthy LDL cholesterol function, enabling the fatty moleculeto efficiently usher excess cholesterol from the body and improve risk factors formany chronic disease conditions.

Green Tea Alters Gene Expression Lower LDL Cholesterol Levels
In one of the first studies ofits type, researchers performed DNA microarray analysis to examine the effectof the active compound found in greentea called epigallocatechin gallate (EGCG). Scientists specificallytargeted the catechin to determine their effect on cholesterol metabolism inHepG2 hepatocytes. They determined that the expression levels of several genesrelated to cholesterol metabolism, including the LDL receptor, were changed byEGCG treatment.

EGCG was found to boost thefunction of the LDL receptor on liver cells. Researchers commented“This is very important as properfunction of the LDL receptor enables your liver to “capture” circulating LDLand recycle it.”  In this study,green tea is shown to alter gene expression toward healthy LDL cholesterolmetabolism by improving receptor acceptance by the liver. The liver displays animproved capacity to capture and filter LDL cholesterol for removal from thebody.

Green Tea Improves Biomarkers to Lower Heart Disease, Cancer andDementia Risks
In addition to the finding that greentea alters LDL cholesterol metabolism, ECGC was found to inhibit genes toreduce the production of Apolipoprotein B (ApoB). ApoB formation is required toinitially form LDL molecules in the blood. Excess production of ApoB is asignificant marker for chronic illnesses ranging from cardiovascular diseaseand heart attack to increased risk of cancer and dementia.

Green tea and the active compoundEGCG are quickly ascending to nutritional “superstar” status. The Chinese haveextolled its virtues for countless generations. Researchers now document theprowess of this nutrient by scientifically validating the direct impact exertedon our genetic structure to affect healthy cholesterol function and removalfrom the body. The healthy benefits of green tea are realized by drinkingseveral fresh brewed cups of organically harvested leaves each day orsupplementing with 250 to 500 mg of EGCG extract.

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