Carnosine Boosts Antioxidant Reserves to Battle Stress, Improve Cognitive Function

Carnosine is a naturallyoccurring antioxidant and metal-chelating nutrient that is shown to minimizethe damaging effects of stress on cellular function. Research presentedin the PLoS One journal explains thatcarnosine can help to drastically reduce the formation of amyloid beta proteinassociated with the brain tangles seen with Alzheimer’s disease.

Our antioxidant defense system isin a continual state of flux, being tested by external pathogens, metabolicglycation and stress that can determine quality of health and risk for disease.Carnosine is shown to boost and recycle existing antioxidants throughout thebody to provide a natural shield against chronic illness, and may specificallyhalt the progression of deadly diseases that lead to dementia and cognitivedysfunction.

Carnosine Supplementation Improves Cellular Energy Production to PreventDementia

Researchers understand that acrucial marker of Alzheimer’sdementia and cognitive decline is the formation of beta-amyloid protein clumpsthat inhibit the normal electrical and neurotransmitter activity required to functionoptimally and form new memories. Until recently scientists have not fullyunderstood if the tangles were the cause or result of dementia. New evidenceexists to support the theory that amyloid plaques form as a result of adeclining ability to naturally clear the protein tangles. Neuroscientists believethat a failure in the energy producing mitochondria where glucose is convertedto ATP is to blame.

The study included mice that havebeen genetically bred to develop a form of dementia that closely resemblesAlzheimer`s disease in humans. Energy-producing mitochondria are susceptible tothe ravages of free radicals and cellular imbalances in metals like copper,iron, and zinc that cause ultimate failure of the organelles leading to numerouschronic diseases. Supplementing the mice with carnosinewas found to “promote a strong reductionin the hippocampal intraneuronal accumulation of amyloid-beta and completelyrescue Alzheimer`s disease and aging-related mitochondrial dysfunctions.”

Carnosine Helps Prevent Glycation and May Provide a Treatment Optionfor Alzheimer’s Disease

Carnosine is a potent antioxidantshown to dramatically lower mitochondrial damage typically caused by stress andglycation (protein-sugar bonds) leading to cellular dysfunction and disease. Thestudy authors went so far as to conclude“Our data indicate that carnosine can bepart of a combined therapeutic approach for the treatment of AD.” This is apowerful conclusion considering that Big Pharma has no approved cure oreffective treatment for this insidious form of dementia.

Carnosine coupled with othernatural nutrients known to be neuroprotective (grape seed extract, resveratrol,curcumin, DHA) can lower the stress placed on critical brain structures andprovide an effective shield against development and progression of disease.Carnosine is found most commonly in beef, pork, poultry and dairy products.Many health-minded individuals avoid a diet centered around animal-derivedfoods and supplementation (1,000 mg per day) has been found to be an effectiveand bioavailable alternative.

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Posted in: Alzheimer's Disease,Carnosine

Carnosine and Carnitine Key to Anti-Aging Health

(Article first published as Anti-Aging Nutrients Carnosine and Carnitine Help Prevent Diabetes and Heart Disease on Technorati.)

Arterial stiffness caused by glycation is one of the key underlying causes of aging and has been shown to contribute to increased risk of heart disease, dementia, DNA damage and metabolic dysfunction. The aging process accelerates as blood sugar levels slowly increase as a result of poor dietary choices and can cause damage to proteins.

Protein structures are rendered useless as they are bound with sugar as combined units known as advanced glycation end products (AGE’s). Carnosine and carnitine are natural compounds that have been shown to prevent the damage caused by excess sugar and can reverse the development of AGE’s that lead to disease proliferation.

Carnosine Shown to Demonstrate Anti-Aging Effects

The heart muscle and vascular system are very sensitive to the effects of free radical damage and protein degradation from sugar glycation. When critical proteins become non-functional from AGE accumulation, the heart and endothelial structures lose their elasticity and blood pressure rises.

The results of research published in the journal Experimental Gerontology demonstrate carnosine’s ability to scavenge and neutralize free radicals and repair damaged protein structures. This was shown to effectively reduce the damaging effects of atherosclerosis and lengthen life span.

Carnosine Reduce Damage from Diabetic Complications

Elevated glucose causes destructive changes to vital enzymes and proteins that set the stage for metabolic syndrome and tissue damage. This problem is particularly devastating in diabetics as blood sugar levels remain elevated throughout the day and sugar-protein cross links wreak havoc with renal health, vision and the nervous system.

Information provided in the journal Mechanisms of Aging and Development shows how carnosine can prevent and even reverse glycation by inhibiting the chemical reaction that links sugar and protein to form non-functional structures. Carnosine effectively stabilizes cellular integrity and helps to prevent the devastating complications that are so common in diabetics.

Carnitine Lowers Risk from Heart Disease

Carnitine is made in the body from the two amino acids lysine and methionine and is essential to lipid metabolism. Research has shown that carnitine is able to lower the damaging effects of free radical damage to the arteries, prevent deterioration of the heart and reduce arterial stiffening. These processes are common in aging individuals and are a key cause of heart disease and heart attack, especially in diabetics.

The European Journal of Clinical Investigation explains how carnitine (Acetyl-l-carnitine) improves arterial flexibility by helping to prevent AGE cross-links that cause hardening of the delicate endothelial structures. The study authors theorize that carnitine may lower levels of oxidized LDL cholesterol that is known to provide the `glue` for compounds that develop into arterial plaque.

Carnosine and carnitine levels in the body naturally decrease with age. The main dietary source for both compounds is from meat and dairy products. Many health conscious people limit their consumption of these foods and supplementation may become necessary. Nutritional experts recommend supplementing with 1000 mg of carnosine and 500 mg of carnitine daily to achieve the antioxidant and anti-aging health benefits experienced in most research studies.

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Posted in: Carnitine,Carnosine,Diabetes,Heart Disease